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. 2010 Jan;332(1):135–144. doi: 10.1124/jpet.109.158261

Fig. 5.

Fig. 5.

TMF fails to induce AHR binding to its cognate response element. A, In vitro translated AHR and ARNT were incubated with vehicle (DMSO), 1 μM β-NF or increasing concentrations of TMF (0.1–20 μM) TMF and 32P-labeled DRE probe added. Samples were resolved on 6% nondenaturing retardation gels and visualized through autoradiography. Specific AHR/ARNT/DRE-retarded bands are indicated. B, in vitro translated AHR and ARNT were incubated with vehicle (DMSO), 1 μM β-NF, or 1 μM β-NF together with TMF (1 or 5 μM) and 32P-labeled DRE probe added. Samples were resolved on 6% nondenaturing retardation gels and visualized through autoradiography. Specific AHR/ARNT/DRE-retarded bands are indicated.

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