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Combined application of GDNF and PEDF (both at 50 ng/ml) restores number of rods and increases percentage of cones. Cryosections of 10-day-old spheroids were triple-stained with DAPI (a, d), the rod-specific antibody rho4D2 (red; b, e), and the red and green cone-specific antibody CERN906 (green; c, f). Data are quantified as percentage of DAPI-stained cells in g and h. Each data point represents the mean ± SD of multiple sections (n = 6). **P < 0.001; **P < 0.0001. Scale bar, 100 μm
