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Progranulin-a is expressed by microglia at the site of photoreceptor injury. Panel a illustrates an in situ hybridization showing pgrna at the site of photoreceptor injury. Panel b is the same section as in a but immunostained with the 4c4 antibody. Panel c is the digital overlay of panels a and b. Arrowheads identify the same cells in a–c. Scale bar = 50 μm. OSL, outer segment layer; ONL, outer nuclear layer; INL, inner nuclear layer
