Table 1.

The number of independent single nucleotide polymorphisms (SNPs) that exceeded a significance threshold of P<10^–5 when the diagnostic subset is compared with the controls (corrected for genomic control, λ)

Diagnostic subset	Genomic control, λ	Observed hits, n	Empirical significance,a (P)
Total bipolar disorder set (n = 1868)	1.116	4	N/A
DSM—IV bipolar I disorder (n = 1594)	1.100	5	0.10
DSM—IV bipolar II disorder (n = 134)	1.002	4	0.27
DSM—IV schizoaffective disorder, bipolar type (n = 98)	1.013	5	0.22
RDC bipolar I disorder (n = 1316)	1.086	0	1.00
RDC bipolar II disorder (n = 171)	1.000	3	0.47
RDC schizoaffective disorder, bipolar type (n = 279)	1.061	9	0.0004
RDC manic disorder (n = 102)	1.025	5	0.20

RDC, Research Diagnostic Criteria; N/A, not applicable.

a. The empirical significance (P) shows how often the observed number of independent hits occurred when sets of participants of the same size were randomly selected from the total set of participants with bipolar disorder (total bipolar disorder set presented for comparison).