Table 2.
Independent association signals at P<10–5 for comparison of participants in the Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type group against controlsa
| Chromosome | Base-pair location | SNP ID | Nearest geneb | P | Supporting SNPs, n |
|---|---|---|---|---|---|
| 21q22.2 | 39959593 | rs4818065 | B3GALT5 (2.9 kb) | 2.32 × 10-7 | 1 |
| 3p21.31 | 49865617 | rs2352974 | TRAIP (0 kb) | 8.27 × 10-7 | 3 |
| 15q26.1 | 87413740 | rs16942644 | ABHD2 (18.7 kb) | 1.38 × 10-6 | 2 |
| 4p12 | 46763337 | rs4279178 | GABRB1 (0 kb) | 2.49 × 10-6 | 1 |
| 5q13.3 | 76431673 | rs13154602 | FLJ18221 (0 kb) | 2.99 × 10-6 | 4 |
| 16p13.3 | 6072788 | rs4786811 | A2BP1 (0 kb kb) | 3.71 × 10-6 | 1 |
| 13q14 | 42297245 | rs7990962 | C13orf30 (33.6 kb) | 5.61 × 10-6 | 4 |
| 2p25.1 | 11954943 | rs4027132 | LPIN1 (70 kb) | 6.63 × 10-6 | 0 |
| 4p12 | 46839864 | rs7680321 | GABRB1 (0 kb) | 7.28 × 10-6 | 3 |
| 6q14.2 | 84286342 | rs1171115 | PRSS35 (0 kb) | 8.36 × 10-6 | 3 |
SNP, single nucleotide polymorphism; ID, identification.
a. ‘Independent’ is defined as linkage disequilibrium r2<0.2. Physical location is given as base-pair location on the chromosome according to genome build 126. The P is the significance of the λ-corrected Cochran—Armitage trend test. The supporting SNPs have P<0.001, lie within 250 kb and are in linkage disequilibrium at r2>0.2 with index SNP. Note that this table contains ten SNPs whereas Table 1 reports nine independent SNPs exceeding P<10-5. This is because rs4786811 did not meet the extremely stringent levels of quality control used in the analysis reported in Table 1.
b. Gene symbol is followed by the distance in kilobase pairs of the SNP from the reference sequence of the gene; 0 kb indicates that the SNP lies within the reference sequence.