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. 2009 Nov 11;29(45):14299–14308. doi: 10.1523/JNEUROSCI.3626-09.2009

Figure 3.

Figure 3.

A MEK inhibitor infused into the BLA blocks inhibitory avoidance retention enhancement induced by posttraining GR agonist infusions into the mPFC. A, Step-through latencies (mean + SEM) in seconds on the 48 h inhibitory avoidance retention test of rats given immediate posttraining infusions of the GR agonist RU 28362 (3 or 10 ng in 0.5 μl) into the left mPFC either alone or together with the MEK inhibitor PD98059 (20 ng in 0.2 μl) into the ipsilateral BLA. ✷✷p < 0.01 compared with the corresponding vehicle group; ♦♦p < 0.01 compared with the corresponding saline–RU 28362 group (n = 10–13 per group). B, Injection needle tips in the left mPFC and BLA of 30 randomly selected rats included in the experiment.