Figure 7.

Effect of GHK normalization of I_K in a model of electrical activity of neurons from the suprachiasmatic nucleus by Sim and Forger (2007). Inset (A) Prediction of the Sim and Forger (2007) model. (B) Prediction of the model when GHK normalization is used to obtain the g_K − V curve from the Bouskila and Dudek (1995)measurements of I_K described to the right. Main panel: description of I_K by Bouskila and Dudek (1995). They normalized their results with (V − E_K) – open circles. The curve describing those results is given by 1/(1 + exp(−(v − 14)/17)). Those points were multiplied by (V − E_K) with E_K = −97 mV, and then normalized by the GHK procedure to give the filled circles. The curve describing those results is given by (α_n/(α_n + β_n)⁴ with α_n = −0.01(V + 30)/(exp(−0.08(V + 30)) − 1) and β_n = 0.125 exp(−(V + 40)/30). This description of I_K predicts quiescence in the Sim and Forger (2007) model as described in the text.