Table 3.

Cardiovascular biomarkers while smoking reduced nicotine yield cigarettes

	Week 1, mean (95% CI)	Week 6, mean (95% CI)	Week 10, mean (95% CI)	Week 6-week 1, mean (95% CI)	Week 10-week 1, mean (95% CI)	Week 10-week 6, mean (95% CI)
Body weight (kg)	77.0 (70.7–83.3)	77.5 (71.0–84.0)	77.4 (71.1–83.7)	1 (−1 to 2)	1 (−1 to 2)	0 (−1 to 1)
Systolic blood pressure (mm Hg)	126.3 (119.4–133.2)	124.8 (118.0–131.6)	126.6 (120.8–132.4)	−1 (−7 to 5)	0 (−6 to 6)	1 (−4 to 7)
Diastolic blood pressure (mm Hg)	80.5 (75.8–85.3)	79.2 (74.8–83.6)	80.0 (76.4–83.5)	−2 (−7 to 4)	−1 (−9 to 8)	1 (−7 to 9)
Heart rate	73.9 (69.1–78.7)	76.1 (69.3–83.0)	75.1 (68.9–81.3)	3 (−7 to 13)	2 (−7 to 11)	−1 (−10 to 7)
WBC count (1,000)	6.5 (5.8–7.3)	6.4 (5.7–7.1)	6.4 (5.8–6.9)	−2 (−12 to 7)	−3 (−16 to 10)	−1 (−14 to 12)
Hemoglobin (%)	14.4 (13.6–15.1)	14.2 (13.4–14.9)	14.3 (13.5–15.1)	−1 (−4 to 2)	0 (−3 to 2)	1 (−1 to 3)
High-density lipoprotein cholesterol (mg/dL)	57.6 (49.1–66.0)	58.3 (48.0–68.7)	59.1 (49.0–69.2)	1 (−8 to 11)	3 (−6 to 11)	1 (−7 to 10)
C-reactive protein* (Ag/mL)	0.87 (0.52–1.45)	0.87 (0.48–1.57)	0.92 (0.53–1.60)	0 (−36 to 57)	6 (−32 to 67)	6 (−32 to 65)
Fibrinogen (mg/dL)	251.8 (216.4–287.1)	223.2 (189.8–256.6)	189.9 (157.4–222.4)	−11 (−25 to 2)	−25 (−48 to −1)	−15 (−36 to 6)

NOTE: Week 1 is while smoking usual brand. Week 6 is while smoking the lowest yield commercial cigarette (0.1 mg nicotine). Week 10 is 4 weeks after the end of reduced nicotine commercial cigarette smoking. Significant differences in bold.

^*Geometric mean.