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Putative mechanism of ranpirnase-mediated cytotoxicity.[46] Cationic and anionic biomolecules are depicted in blue and red, respectively. (A) Ranpirnase (blue) forms an extracellular equilibrium complex with cell-surface heparan sulfate (red). (B) Ranpirnase is internalized by endocytosis, translocates to the cytosol, evades the ribonuclease inhibitor protein (red horseshoe), and degrades tRNA (red line). (C) tRNA degradation leads to apoptosis.
