Figure 2.

Membrane ruffling of fibroblast in 3D collagen matrix. The dendritic extensions of fibroblasts in 3D collagen matrices expanded in response to PDGF and retracted in response to LPA stimulation (Upper panel). Membrane ruffling was induced at the margin of the membrane in both PDGF- and LPA-stimulated fibroblasts (Low panel), which provides mechanical activity for the floating matrix. Rho kinase and mDia interacted with PAK1 for PDGF and LPA-mediated matrix contraction, respectively. See Figure 3 and 10 in (Rhee and Grinnell, 2006) for more detail.