Table 3.
Human leucocyte antigen (HLA) class II molecule binding activity of E6/2 (14–34) and E6/4 (45–64) peptides.
| Relative binding activity |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Peptides | DR1 | DR3 | DR4 | DR7 | DR11 | DR13 | DR15 | DRB3 | DRB4 | DRB5 | Number HLA II |
| E6/2 (14–34) | 632 | 8 | > 333 | 5 | > 577 | > 30 | 71 | 169 | 1167 | > 1208 | 3 |
| E6/4 (45–68) | 9 | 167 | 58 | 51 | 7 | > 30 | 6 | 293 | >3593 | 8 | 6 |
Peptide binding capacity was investigated by competitive enzyme-linked immunosorbent assays. Data are expressed as relative activity [ratio of the inhibitory concentration (IC50) of the peptide by the IC50 of the reference peptide. which is a high binder to the HLA class II molecule]. Relative activities inferior to 100 correspond to active peptides. Means were calculated from at least three independent experiments.