Fig. 1.

Collagen antibody-induced arthritis (CAIA) in wild-type (WT) mice, Df^−/− mice (a, b), MBL^−/−/Df^−/−- mice (classical pathway only) (c, d) and C1q^−/−/Df^−/− mice (lectin pathway only) (e, f). The mice were injected intraperitoneally with a cocktail of four monoclonal antibodies (mAb) to type II collagen. Lipopolysaccharide (LPS) was administered on day 3 to synchronize the development of arthritis. The data are expressed as the incidence of arthritis (a, c, e) and clinical disease activity score (b, d, f) versus days after the mAb injection. The data represent the mean ± standard error of the mean based on n = 5 for the Df^−/− mice, n = 4 for the MBL^−/−/Df^−/− and C1q^−/−/Df^−/− mice and n = 4 for each set of WT mice.