Table 1.

Histopathology scores and C3 deposition in the joints of wild-type (WT) and complement-deficient mice.

Histopathology†
Mouse type	Inflammation	Pannus	Cartilage damage	Bone damage	Total
WT (n = 4)	2.70 ± 0.17	3.00 ± 0.12	2.45 ± 0.15	2.70 ± 0.13	10.9 ± 0.53
Df−/− (n = 5)	1.12 ± 0.17	1.44 ± 0.17	1.28 ± 0.26	1.32 ± 0.22	5.16 ± 0.79
P	< 0.001	< 0.001	< 0.01	< 0.001	< 0.001
WT (n = 4)	1.35 ± 0.28	1.15 ± 0.29	1.20 ± 0.54	0.95 ± 0.12	4.65 ± 1.34
MBL−/−/Df−/− (n = 4)	0.40 ± 0.08	0.40 ± 0.08	0.50 ± 0.10	0.40 ± 0.08	1.70 ± 0.13
P	< 0.01	< 0.02	< 0.12	< 0.06	< 0.04
WT (n = 4)	3.15 ± 0.05	2.60 ± 0.14	2.55 ± 0.05	2.60 ± 0.14	10.9 ± 0.26
C1q−/−/Df−/− (n = 4)	0.45 ± 0.10	0.40 ± 0.08	0.70 ± 0.24	0.40 ± 0.08	1.95 ± 0.43
P	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001
C3 Deposition†
Mouse type	Synovium	Cartilage	Total
WT (n = 4)	2.75 ± 0.13	2.10 ± 0.17	4.85 ± 0.28
Df−/− (n = 5)	1.60 ± 0.14	1.04 ± 0.10	2.64 ± 0.21
P	< 0.001	< 0.001	< 0.0003
WT (n = 4)	2.00 ± 0.29	1.30 ± 0.30	3.30 ± 0.58
MBL−/−/Df−/− (n = 4)	1.00 ± 0.08	0.90 ± 0.10	1.90 ± 0.13
P	< 0.01	< 0.13	< 0.03
WT (n = 4)	2.60 ± 0.08	2.30 ± 0.29	4.90 ± 0.33
C1q−/−/Df−/− (n = 4)	0.80 ± 0.08	0.50 ± 0.06	1.30 ± 0.13
P	< 0.0001	< 0.001	< 0.0001

^†Five joints were examined in each animal and the results expressed as mean ± standard error of the mean for the indicated number of mice.