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. 2009 Oct-Dec;3(4):361–364. doi: 10.4161/cam.3.4.9525

Figure 1.

Figure 1

Structural organization of HDs. (A) Schematic representation of the components of the type I HDs and the interactions that link the adhesion receptors to the IF cytoskeleton. Homo-associations have been omitted for clarity. (B) Domain organization of the N-terminal region of plectin and (C) the cytoplasmic region of the integrin β4 subunit. (D) Composite structure of the primary β4-plectin complex (PDB code 3F7P) and adjacent regions, which include the structure of the Calx-β domain of β4 (PDB code 3FQ4) and the first pair of SRs of the plakin domain of plectin (PDB code 2ODU). The relative orientations of the structures of the Calx-β domain of β4 and the SR1-SR2 fragment of plectin with respect to the β4-plectin complex were arbitrarily chosen for representation purposes. The Calx-β is connected to the FnIII-1 domain by a ∼20 residues-long linker, while the sequence that connects the CH2 to the SR1 of plectin is ∼10 residues-long. In both cases, these linkers (shown as dashed lines) are likely to act as flexible joints.