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. Author manuscript; available in PMC: 2010 Apr 17.
Published in final edited form as: Cell. 2009 Apr 17;137(2):259–272. doi: 10.1016/j.cell.2009.02.045

Figure 7. Model for regulation of histone acetylation by H3K4 and K36 methylation.

Figure 7

At 5′ ends of genes, RNApII recruits the Set1-COMPASS complex, which methylates histone H3K4. HATs such as SAGA, NuA3, and NuA4 direct histone acetylation to promoters by interacting with upstream regulatory factors and/or trimethylated H3K4. Just downstream, H3K4me2 serves as a binding site for the Set3 PHD finger. The resulting association of Set3C facilitates histone deacetylation by the Hos2 and Hst1 subunits. Further downstream, interaction of Set2 with Ser2-phosphorylated RNApII leads to methylation of H3K36. This mark recruits Rpd3C(S) via the Eaf3 chromodomain, leading to deacetylation of histones in 3′ regions of genes.