Figure 6.

Proposed model of EGR1 downregulation in SIVE. A, EGR1 protein binding partners in the protein interaction network (—) and high-confidence gene targets (—|) taken from James et al. (2005) (their Table 1), in which Irf7 appears twice, once with p = 0.0025 and once with p = 0.05. Rat gene names were associated with human Entrez Gene IDs using Entrez Gene Symbols and aliases. B, Schematic depiction of proposed mechanism of EGR1 downregulation by chemokines in SIV-infected hippocampus and consequent reduced neuroplasticity.