Igfbp5−/− mice exhibit increased postnatal body weight. A, Body weights were measured on 14- to 16-h fasted male mice between 8 and 10 wk of age (n = 9–24). Error bars indicate se. *, P < 0.01 for Igfbp5−/− and Igfbp5−/−;myrAkt1 TG compared with NTG or myrAkt1 TG mice. Growth curves for male (B) and female (C) mice. Weights were monitored on random fed mice beginning 1 wk after birth and once per week thereafter for 12 wk and then every 2 wk until 14 wk (males, n = 10–12; females, n = 7–9). Error bars indicate se. *, P < 0.01 for Igfbp5+/+ vs. Igfbp5−/− mice. D, DEXA analysis; E, body length.