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BRCA1-I26A mutation does not abrogate BRCA1 association with ER-α in vivo. A, HCC1937 cells, which do not express wtBRCA1, were transfected as indicated and subjected to immunoprecipitation (IP) for ER-α and Western blotting for BRCA1 and ER-α. B and C, Western blots are provided to show the expression of exogenous ER-α (B) and BRCA1 (C) proteins.
