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Effect of chronic MC3/4R antagonism with SHU-9119 during α- and β-adrenergic receptor blockade with propranolol and terazosin on (A) mean arterial pressure and (B) heart rate in SHR (n=6) and WKY (n=5). The delta change in mean arterial pressure and heart rate represents the average of the last 5 days of SHU-9119 infusion. *P<0.05 vs α/β blockade alone.
