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. 2009 Feb 18;29(7):1962–1976. doi: 10.1523/JNEUROSCI.5351-08.2009

Figure 6.

Figure 6.

Striatum DA terminal loss in Parkin-Q311X mice. A, Representative Western blot demonstrating striatal TH levels in transgenic mice from line A and wild-type littermate controls at 12 months of age. Quantification of TH bands confirmed that striatal TH levels were significantly lower in Parkin-Q311X(A) mice than in wild-type littermate controls. n = 8 per genotype. *p < 0.05 compared with wild-type littermates. B, Representative photographs showing the TH immunohistochemistry staining in striatum of wild-type (top) and Parkin-Q311X(A) mice at 16–18 months of age. C, Quantification of TH immunofluorescence using a microarray scanner in 16-month-old mice. In rostral striatum, dorsolateral and ventrolateral striatal TH levels were significantly lower in Parkin-Q311X(A) mice than in wild-type littermate controls. n = 4 per genotype. *p < 0.05 compared with wild-type littermates. Error bars indicate SEM.