Figure 7.

Reduced striatal DA and metabolite content in Parkin-Q311X mice and the correlation with behavioral deficits. A–C, Striatal DA, DOPAC, and HVA content measured using HPLC-ECD, in Parkin-Q311X(A) mice at 19–21 months of age. Results are expressed as picomoles per milligram of tissue [WT, n = 10; Parkin-Q311X(A), n = 7; *p < 0.05 compared with wild-type littermates]. Error bars indicate SEM. D, E, Total activity (D) and vertical plane entries (E) in open-field test were examined in wild-type littermates (blue squares) and Parkin-Q311X(A) mice (red squares) at 19–21 months of age and correlated with striatal DA levels.