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. 2009 Feb 18;29(7):1962–1976. doi: 10.1523/JNEUROSCI.5351-08.2009

Figure 8.

Figure 8.

Accumulation of proteinase K-resistant α-synuclein in nigra of Parkin-Q311X(A) mice. A, B, Photomicrographs of the midbrain sections of Parkin-Q311X(A) mice and wild-type littermates at 3 months of age immunostained for proteinase K-resistant α-synuclein. Scale bar, 50 μm. C–F, Adjacent midbrain sections of Parkin-Q311X(A) mice and wild-type littermates at 16–18 months of age were immunostained for TH (C, D) (scale bar, 50 μm), proteinase K-resistant α-synuclein (E, F) (scale bar, 50 μm), and higher-magnification microphotographs of α-synuclein-immunopositive cells in nigra (insets in C and D) (scale bar, 12.5 μm).