Table 3.

Univariate and multivariate hazard ratios of tested predictors

Predictor	Unadjusted hazard ratio (95% CI), and P value	Adjusted hazard ratio (95% CI), and P value
LIC	2.61(1.37–4.99), P=0.004	2.50(1.31–4.79), P=0.005
NYHA class	2.69(1.99–3.63), P<0.0001	2.99(1.45–6.15), P=0.003
Time-dependent appropriate
ICD shocks	2.67(1.41–5.05), P=0.003	6.71(1.52–29.64), P=0.012
LVEF	0.95(0.92–0.97), P<0.0001	0.94(0.90–0.97), P<0.0001
Diabetes mellitus	1.73(1.09–2.72), P=0.019	1.50(0.78–1.58), P=0.221
Single-chamber ICD device	0.65(0.41–1.05), P=0.077	0.73(0.34–1.58), P=0.423
History of Hypertension	1.92(1.01–3.65), P=0.045	2.10(0.81–5.43), P=0.126
Digitalis	2.02(1.28–3.18), P=0.003	1.47(0.76–2.83), P=0.252
Aldosterone antagonists	2.02(1.28–3.18), P=0.003	1.70(0.87–3.34), P=0.122
Cycle length of induced VF	1.00(0.98–1.01), P=0.755	1.00(0.99–1.02), P=0.741
Atrial Fibrillation	3.15(1.68–5.91), P<0.0001	2.39(0.90–6.34), P=0.080
African-American Race	3.00(1.86–4.84), P<0.0001	1.91(0.93–3.89), P=0.077
Renal Failure	2.68(1.34–5.37), P=0.005	2.08(0.80–5.44), P=0.134
Age	1.00(0.99–1.02), P=0.476	1.00(0.97–1.02), P=0.725

Each multivariate test includes LIC, time-dependent appropriate ICD shocks, NYHA class, and then tested other covariates one by one. Ejection fraction was tested in the model without NYHA class. Hazard ratio of appropriate ICD shock at follow up indicates the relative risk of the death or hospitalization due to CHF exacerbation per year from the first appropriate ICD shock.