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. Author manuscript; available in PMC: 2010 Jul 2.
Published in final edited form as: Nature. 2009 Jun 3;460(7251):103–107. doi: 10.1038/nature08097

Figure 2. TRAF6 intrinsically regulates CD8 TM generation.

Figure 2

OT-I cells (<5000) from OTI-TRAF6-WT and OTI-TRAF6-ΔT (CD45.2) (a–c) or CA-St5-OTI-TRAF6-WT and CA-St5-OTI-TRAF6-ΔT mice (CD45.2) (d,e) were transferred into CD45.1 recipients (n=5–9 per group) and LmOva-immunized. Three weeks post-transfer immune (a–d) or unimmunized mice (e) were LmOva-challenged. Mice were bled as indicated and cells surface stained. Dot plots show donor cells by CD45.2 and Kb/Ova tetramer (numbers indicate total CD8 T cell percentages that are host- or donor-derived). Line graphs represent percentages of donor-derived CD8 T cells (means ± standard deviation).