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. Author manuscript; available in PMC: 2010 Jan 7.
Published in final edited form as: Nat Chem Biol. 2007 Jun 3;3(7):415–419. doi: 10.1038/nchembio.2007.2

Fig. 2.

Fig. 2

Structure of the Mth ectodomain in complex with the R8-01 15-mer peptide. (a) Electron density reveals the putative peptide binding site on the Mth ectodomain (shown as a ribbon diagram) from an averaged 3.5 Å FO – FC map contoured at 9 σ. Trp120 (a previously proposed natural ligand binding site9), Tyr130 (at the R8-01 binding site), and Asp46 and Phe153 (suggested to interact with the extracellular face of the TM domain9) are shown as stick models. (b) Scaled model depicting the full-length structure of Mth (adapted from 9). The TM domain is depicted by the structure of rhodopsin30 as a representative GPCR.