Table 4.
Breast density (Mean, SE) and Change in Breast density by Randomization Group
| Mean (SE) | Difference in means (No suspension is reference group) |
||||
|---|---|---|---|---|---|
| No- suspension |
1-month suspension |
2-months suspension |
1-month suspension vs. No- suspension |
2-months suspension vs. No-suspension |
|
| # Mammograms completed | 541 | 478 | 452 | β (95% CI) | β (95% CI) |
| Percent Dense Area (%) | |||||
| All study participants | |||||
| Index mammogram | 24.4 (0.6) | 24.1 (0.7) | 24.1 (0.7) | −0.30 (−2.15, 1.55) | −0.38 (−2.26, 1.50) |
| Study mammogram | 24.5 (0.6) | 23.2 (0.7) | 22.6 (0.7) | −1.34 (−3.19, 0.51) | −1.98 (−3.85, −0.10) |
| Change in % dense | 0.1 (0.3) | −0.9 (0.3) | −1.5 (0.4) | −1.04 (−1.93, −0.15) | −1.60 (−2.50, −0.70) |
| Estrogen only at baseline | |||||
| Index mammogram | 22.9 (0.8) | 23.0 (0.9) | 22.7 (0.9) | 0.14 (−2.14, 2.42) | −0.22 (−2.52, 2.07) |
| Study mammogram | 22.7 (0.8) | 22.3 (0.9) | 21.6 (0.9) | −0.33 (−2.61, 1.95) | −1.12 (−3.42, 1.19) |
| Change in % dense | −0.2 (0.4) | −0.7 (0.4) | −1.1 (0.4) | −0.47 (−1.57, 0.63) | −0.89 (−2.00, 0.22) |
| Estrogen + progestin at baseline | |||||
| Index mammogram | 27.0 (1.1) | 25.9 (1.2) | 26.5 (1.2) | −1.03 (−4.15, 2.08) | −0.49 (−3.69, 2.71) |
| Study mammogram | 27.6 (1.1) | 24.6 (1.1) | 24.3 (1.2) | −3.00 (−6.09, 0.09) | −3.28 (−6.46, −0.11) |
| Change in % dense | 0.6 (0.5) | −1.3 (0.6) | −2.2 (0.6) | −1.96 (−3.45, −0.48) | −2.79 (−4.31, −1.27) |
| Dense Area (cm2) | |||||
| All study participants | |||||
| Index mammogram | 30.5 (0.9) | 31.9 (1.0) | 30.3 (1.0) | 1.38 (−1.26, 4.02) | −0.17 (−2.85, 2.51) |
| Study mammogram | 30.1 (0.8) | 30.4 (1.0) | 27.5 (0.9) | 0.30 (−2.13, 2.74) | −2.57 (−5.04, −0.10) |
| Change in area | −0.5 (0.5) | −1.5 (0.5) | −2.9 (0.5) | −1.07 (−2.37, 0.22) | −2.40 (−3.71, −1.08) |
| Estrogen only at baseline | |||||
| Index mammogram | 30.2 (1.1) | 31.0 (1.2) | 30.8 (1.3) | 0.86 (−2.47, 4.20) | 0.58 (−2.78, 3.94) |
| Study mammogram | 29.0 (1.0) | 29.8 (1.1) | 27.9 (1.2) | 0.80 (−2.23, 3.82) | −1.07 (−4.13, 1.98) |
| Change in area | −1.2 (0.6) | −1.3 (0.6) | −2.9 (0.7) | −0.07 (−1.78, 1.65) | −1.65 (−3.38, 0.07) |
| Estrogen + progestin at baseline | |||||
| Index mammogram | 31.1 (1.5) | 33.3 (1.8) | 29.6 (1.4) | 2.20 (−2.14, 6.54) | −1.43 (−5.88, 3.03) |
| Study mammogram | 31.8 (29.0) | 31.3 (1.7) | 26.8 (1.3) | −0.51 (−4.59, 3.58) | −5.04 (−9.24, −0.85) |
| Change in area | 0.8 (0.7) | −1.9 (0.7) | −2.8 (0.8) | −2.71 (−4.66, −0.75) | −3.61 (−5.62, −1.61) |