Skip to main content
. Author manuscript; available in PMC: 2010 Jan 7.
Published in final edited form as: Ann Intern Med. 2009 Jun 2;150(11):752–765. doi: 10.7326/0003-4819-150-11-200906020-00003

Table 5.

Mean of Symptom Severity Scores by Intervention Group at Baseline and Follow-up and Change in Severity of Symptoms

Baseline Questionnaire Follow-up Questionnaire
No
Suspension
(n = 529)*
1-month
Suspension
(n = 465)
2-month
Suspension
(n = 444)
p-
Value
No
Suspension
(n = 527)
1-month
Suspension
(n = 462)
2-month
Suspension
(n = 443)
p-
Value
Hot flashes/night sweats, %
Do you have hot flashes or night sweats? .40 <.001
    No 48.7 51.7 52.8 49.9 15.0 11.6
    Yes 51.3 48.3 47.2 50.1 85.0 88.4
Among women who have hot flashes or night sweats: n = 268 n = 223 n = 208 n = 262 n = 390 n = 388
How many hot flashes plus night sweats per day? 0.145 <.001
    < 1 per day 56.3 52.0 44.2 48.9 17.7 11.1
    1–2 per day 23.1 24.7 36.5 30.5 19.2 17.3
    3–4 per day 13.4 14.8 13.0 13.4 22.6 20.9
    5–6 per day 3.7 3.1 4.3 5.0 16.9 20.1
    > 6 per day 2.6 4.5 1.9 1.9 23.1 29.9
    missing 0.8 0.9 0.0 0.4 0.5 0.8
Intensity of hot flashes .76 <.001
    Mild 47.0 48.9 52.9 54.6 29.7 21.4
    Moderate 38.1 38.6 34.6 34.4 53.6 56.2
    Severe 4.9 5.4 6.3 5.3 14.4 20.6
    missing 10.1 7.2 6.3 5.7 2.3 1.8
Intensity of night sweats .31 <.001
    Mild 26.9 18.8 22.1 29.0 18.7 12.6
    Moderate 32.8 36.8 36.1 34.0 25.9 24.2
    Severe 37.7 40.8 39.9 35.1 53.9 61.1
    Missing 2.6 3.6 1.9 1.9 1.5 2.1
How much do night sweats interfere with sleep? .007 <.001
    Do not interfere 20.9 13.5 16.4 19.5 14.6 9.0
    Woke up, right back to sleep 55.6 52.0 63.5 57.6 43.9 47.2
    Kept me awake 20.2 29.6 17.3 19.9 37.7 39.2
    Ruin my night 0.8 0.9 1.4 1.2 2.3 2.8
    Missing 2.6 4.0 1.4 1.9 1.5 1.8
Sleep, mean (SD)
Importance of good night’s sleep 9.0 (1.5) 8.9 (1.6) 9.0 (1.5) .47 8.9 (1.7) 8.7 (1.9) 8.7 (1.7) .074
Sleep Disturbance Scale 2.60 (1.42) 2.54 (1.42) 2.57 (1.41) .77 2.55 (1.45) 2.98 (1.51) 3.13 (1.46) <.001
Menopausal symptoms, mean (SD)
Menopausal symptom scale 1.92 (1.33) 1.99 (1.48) 2.01 (1.47) .57 1.81 (1.33) 2.48 (1.73) 2.89 (1.76) <.001
Vasomotor symptom sub-scale 1.71 (2.20) 1.85 (2.44) 1.93 (2.43) .35 1.64 (2.12) 4.31 (2.99) 5.30 (2.91) <.001
Forgetfulness 2.6 (2.4) 2.5 (2.4) 2.6 (2.4) .82 2.4 (2.4) 2.2 (2.7) 2.6 (2.8) .024
Mood swings 1.3 (1.8) 1.5 (2.1) 1.5 (1.9) .31 1.2 (1.8) 1.9 (2.7) 2.2 (2.7) <.001
Trouble concentrating 2.0 (2.4) 1.9 (2.3) 2.1 (2.3) .52 1.8 (2.3) 2.2 (2.8) 2.6 (2.9) <.001
Vaginal bleeding 0.1 (0.7) 0.1 (0.7) 0.1 (0.7) .99 0.1 (0.8) 0.2 (0.8) 0.1 (0.8) .81
*

Number returning questionnaire

Subscale of the Wiklund(28, 29) symptom checklist, which includes hot flashes and night sweats

General Sleep Disturbance Scale(27, 58) average score across sleep difficulty questions