Table 5.
Mean of Symptom Severity Scores by Intervention Group at Baseline and Follow-up and Change in Severity of Symptoms
| Baseline Questionnaire | Follow-up Questionnaire | |||||||
|---|---|---|---|---|---|---|---|---|
| No Suspension (n = 529)* |
1-month Suspension (n = 465) |
2-month Suspension (n = 444) |
p- Value |
No Suspension (n = 527) |
1-month Suspension (n = 462) |
2-month Suspension (n = 443) |
p- Value |
|
| Hot flashes/night sweats, % | ||||||||
| Do you have hot flashes or night sweats? | .40 | <.001 | ||||||
| No | 48.7 | 51.7 | 52.8 | 49.9 | 15.0 | 11.6 | ||
| Yes | 51.3 | 48.3 | 47.2 | 50.1 | 85.0 | 88.4 | ||
| Among women who have hot flashes or night sweats: | n = 268 | n = 223 | n = 208 | n = 262 | n = 390 | n = 388 | ||
| How many hot flashes plus night sweats per day? | 0.145 | <.001 | ||||||
| < 1 per day | 56.3 | 52.0 | 44.2 | 48.9 | 17.7 | 11.1 | ||
| 1–2 per day | 23.1 | 24.7 | 36.5 | 30.5 | 19.2 | 17.3 | ||
| 3–4 per day | 13.4 | 14.8 | 13.0 | 13.4 | 22.6 | 20.9 | ||
| 5–6 per day | 3.7 | 3.1 | 4.3 | 5.0 | 16.9 | 20.1 | ||
| > 6 per day | 2.6 | 4.5 | 1.9 | 1.9 | 23.1 | 29.9 | ||
| missing | 0.8 | 0.9 | 0.0 | 0.4 | 0.5 | 0.8 | ||
| Intensity of hot flashes | .76 | <.001 | ||||||
| Mild | 47.0 | 48.9 | 52.9 | 54.6 | 29.7 | 21.4 | ||
| Moderate | 38.1 | 38.6 | 34.6 | 34.4 | 53.6 | 56.2 | ||
| Severe | 4.9 | 5.4 | 6.3 | 5.3 | 14.4 | 20.6 | ||
| missing | 10.1 | 7.2 | 6.3 | 5.7 | 2.3 | 1.8 | ||
| Intensity of night sweats | .31 | <.001 | ||||||
| Mild | 26.9 | 18.8 | 22.1 | 29.0 | 18.7 | 12.6 | ||
| Moderate | 32.8 | 36.8 | 36.1 | 34.0 | 25.9 | 24.2 | ||
| Severe | 37.7 | 40.8 | 39.9 | 35.1 | 53.9 | 61.1 | ||
| Missing | 2.6 | 3.6 | 1.9 | 1.9 | 1.5 | 2.1 | ||
| How much do night sweats interfere with sleep? | .007 | <.001 | ||||||
| Do not interfere | 20.9 | 13.5 | 16.4 | 19.5 | 14.6 | 9.0 | ||
| Woke up, right back to sleep | 55.6 | 52.0 | 63.5 | 57.6 | 43.9 | 47.2 | ||
| Kept me awake | 20.2 | 29.6 | 17.3 | 19.9 | 37.7 | 39.2 | ||
| Ruin my night | 0.8 | 0.9 | 1.4 | 1.2 | 2.3 | 2.8 | ||
| Missing | 2.6 | 4.0 | 1.4 | 1.9 | 1.5 | 1.8 | ||
| Sleep, mean (SD) | ||||||||
| Importance of good night’s sleep | 9.0 (1.5) | 8.9 (1.6) | 9.0 (1.5) | .47 | 8.9 (1.7) | 8.7 (1.9) | 8.7 (1.7) | .074 |
| Sleep Disturbance Scale‡ | 2.60 (1.42) | 2.54 (1.42) | 2.57 (1.41) | .77 | 2.55 (1.45) | 2.98 (1.51) | 3.13 (1.46) | <.001 |
| Menopausal symptoms, mean (SD) | ||||||||
| Menopausal symptom scale | 1.92 (1.33) | 1.99 (1.48) | 2.01 (1.47) | .57 | 1.81 (1.33) | 2.48 (1.73) | 2.89 (1.76) | <.001 |
| Vasomotor symptom sub-scale† | 1.71 (2.20) | 1.85 (2.44) | 1.93 (2.43) | .35 | 1.64 (2.12) | 4.31 (2.99) | 5.30 (2.91) | <.001 |
| Forgetfulness | 2.6 (2.4) | 2.5 (2.4) | 2.6 (2.4) | .82 | 2.4 (2.4) | 2.2 (2.7) | 2.6 (2.8) | .024 |
| Mood swings | 1.3 (1.8) | 1.5 (2.1) | 1.5 (1.9) | .31 | 1.2 (1.8) | 1.9 (2.7) | 2.2 (2.7) | <.001 |
| Trouble concentrating | 2.0 (2.4) | 1.9 (2.3) | 2.1 (2.3) | .52 | 1.8 (2.3) | 2.2 (2.8) | 2.6 (2.9) | <.001 |
| Vaginal bleeding | 0.1 (0.7) | 0.1 (0.7) | 0.1 (0.7) | .99 | 0.1 (0.8) | 0.2 (0.8) | 0.1 (0.8) | .81 |
*
Number returning questionnaire
†
Subscale of the Wiklund(28, 29) symptom checklist, which includes hot flashes and night sweats
‡
General Sleep Disturbance Scale(27, 58) average score across sleep difficulty questions