Table 2. Presenting Clinical Characteristics Based on Whether Patient had Alternative Diagnosis to Explain Symptoms.

Charts were reviewed and patients were determined to have abnormal laboratory values (hepatitis (ALT > 3× upper limit of noraml) or leukopenia (WBC < 4.0 thousand per microliter)). Documentation of initial history and physical was reviewed to determine clinical signs of fever (Tm < 100.5), CNS symptoms (AMS or obtundation), skin lesions, sepsis (hypotension requiring pressors and tachycardia), abdominal complaints, or respiratory failure (mechanical ventilation). Patient who had no alternative diagnosis to explain symptoms had negative bacterial cultures or PCR-confirmed HSV meningitis.

Condition	HSV Viremia without Alternative Explanation for Acute Illness (n=8)	HSV Viremia with Other Potential Diagnoses to Explain Acute Illness (n=5)	Total (n=13)
Hepatitis	75	40	62
Fever (72h)	75	20	54
Mortality	50	60	54
Leukopenia	50	40	46
CNS	50	40
symptoms			46
Sepsis	50	20	38
Skin lesions	25	60	38
Abd Pain	50	0	31
Respiratory	25	20
Failure			23