Table 2.
Geometric mean (GM) and relative standard error (GRSE%) voriconazole PK parameter estimates in CHLA patients stratified by age. Published values in children 2–12 years of age [4] are provided for comparison.
| CHLA ≥12 y (n=18) | CHLA <12 y (n=22) | Published 2–12 y | ||||
|---|---|---|---|---|---|---|
| GM | GRSE% | GM | GRSE% | Mean | RSE% | |
| Ka (h−1) | 0.43 | 212 | 0.51 | 164 | 0.85 | 40 |
| CL (L/kg/h) | 0.20 | 170 | 0.32* | 125 | 0.58 | 19 |
| Vc (L/kg) | 0.17 | 188 | 0.27* | 188 | 0.81 | 14 |
| Q (L/kg/h) | 0.68 | 191 | 0.43 | 246 | 0.61 | 13 |
| Vp (L/kg) | 0.83 | 127 | 2.34* | 42 | 2.17 | 11 |
| Km (mg/L) | 7.84 | 5 | 5.16 | 9 | 3.03 | 45 |
| F (%) | 81 | 37 | 75 | 35 | 45 | 14 |
| Tlag (h) | 4.14 | 11 | 4.17 | 13 | - | - |
Abbreviations: Ka=Rate constant of absorption; CL=Clearance; Vc=Volume of the central compartment; Q=Intercompartmental clearance; Vp=Volume of the peripheral compartment; Km=Michaelis-Menten constant; F=Bioavailability; Tlag=lag (delay) prior to absorption;
*
P≤0.05 for comparison between CHLA patients <12 y and ≥12 y by Student’s T-test.