Figure 8.

Proposed model to account for the effects of prenatal T on P₄ negative feedback. Schematic diagram showing the decrease in DYN expression without a change in kisspeptin in KNDy neurons of prenatal T-treated ewes, which is proposed to shift the balance of excitatory (green) and inhibitory (red) neuropeptide inputs to GnRH neurons, and the consequent ability of P₄ to inhibit GnRH/LH pulses. For simplicity, and because it is unlikely that changes in NKB contribute to P₄ negative feedback (see Discussion), NKB is not included in the diagram.