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. 2009 Nov 11;151(1):32–42. doi: 10.1210/en.2009-0855

Figure 6.

Figure 6

Enhanced inhibition of BCa cell growth by calcitriol-AI combinations. A, Calcitriol inhibits T stimulation of MCF-7 growth. Cells were grown in steroid-depleted media containing vehicle (control, open bar) or 100 nm T in the absence (solid bar) or presence of the indicated concentrations of calcitriol or 10 μm Cdx for 6 d. DNA contents were determined and shown as a percentage of vehicle-treated control set at 100%, which corresponded to 22.1 ± 1 μg/well. **, P < 0.01 and ***, P < 0.001 compared with control; ##, P < 0.01 and ###, P < 0.001 compared with T. B–D, Enhanced inhibition of cell growth by calcitriol-AI combinations. Cells were grown as described in A in the absence or presence of calcitriol (Cal), exemestane (Exe, 6b), anastrozole (Ana, 6c), letrozole (Let, 6d), or combinations of calcitriol with each AI at the indicated concentrations. DNA contents are shown as a percentage of vehicle-treated control set at 100%, which corresponded to 20 ± 1.2 μg/well. ***, P < 0.001 compared with control; ##, P < 0.01, ###, P < 0.001 compared with T; +, P < 0.05; ++, P < 0.01; and +++, P < 0.001 compared with the corresponding doses of calcitriol; ^, P < 0.05; ^, P < 0.01; and ^^, P < 0.01 compared with the corresponding doses of exemestane, letrozole, or anastrozole.