TABLE 1.

Structure-based mutagenesis of LDL-R

Class	Location in Structure	Comment
Linker/Hinge mutations:
G293S	Hinge R7, EGF-A
F362A	Interface EGF-B, β-propeller
G375S	Hinge EGF-B, β-propeller	FH mutationa
Histidine cluster:
H190Y	R5	FH mutation
H562Y	β-propeller	FH mutation
H586Y	β-propeller
R4, R5, β-propeller interface:
W144A	R4
W193A	R5
W515A	β-propeller
W541A	β-propeller
K560W	β-propeller
K582W	β-propeller

^aMutation found in FH patients.