Fig. 2.

Association between the concentration of HDL cholesterol and severity of the NPC1 biochemical phenotype. The concentration of HDL cholesterol and biochemical phenotype score from 19 NPC1 patients, as presented in Table 5, was analyzed using Spearman's rank correlation coefficient analysis. The biochemical phenotype score was calculated as described in the Methods and defined as: 2 = moderate, 3 = classical, 4 = severe. The results indicated a significant inverse correlation (−0.66, P = 0.005) between the concentration of HDL cholesterol and biochemical phenotype score.