TABLE 1.
Average concentration of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides for normal individuals and NPC1 patients based on both gender and age
| Total Cholesterol | HDL Cholesterol | LDL Cholesterol | Triglycerides | |
|---|---|---|---|---|
| Normal Males | 159.9 ± 0.7 | 55.8 ± 1.0 | 92.5 ± 1.8 | 55.7 ± 0.6 |
| Age 5–9 Years | 4.13 ± 0.0 | 1.44 ± 0.0 | 2.39 ± 0.0 | 0.63 ± 0.0 |
| N = 1253 | N = 145 | N = 132 | N = 1253 | |
| NPC1 Males | 149.3 ± 15.0 | 34.4 ± 7.1 | 86.9 ± 15.0 | 136.3 ± 21.6 |
| Age 7.9 ± 1.4 Years | 3.86 ± 0.4 | 0.89 ± 0.8 | 2.25 ± 0.4 | 1.54 ± 0.2 |
| N = 7 | N = 7 | N = 7 | N = 7 | |
| Significance | NS | P = 0.02 | NS | P = 0.01 |
| Normal Females | 163.7 ± 0.7 | 53.2 ± 1.0 | 100.4 ± 2.1 | 60.3 ± 0.8 |
| Age 5–9 Years | 4.23 ± 0.0 | 1.38 ± 0.0 | 2.60 ± 0.07 | 0.68 ± 0.0 |
| N = 1118 | N = 127 | N = 114 | N = 1118 | |
| NPC1 Females | 124.6 ± 7.0 | 30.3 ± 3.0 | 75.0 ± 6.7 | 99.3 ± 9.5 |
| Age 9.9 ± 0.9 Years | 3.22 ± 0.3 | 0.78 ± 0.1 | 1.94 ± 0.2 | 1.12 ± 0.1 |
| N = 6 | N = 6 | N = 6 | N = 6 | |
| Significance | P = 0.003 | P = 0.001 | P = 0.01 | P = 0.01 |
| Normal Males | 182.2 ± 0.8 | 44.7 ± 0.7 | 116.7 ± 1.9 | 115.8 ± 2.3 |
| Age 25–29 Years | 4.71 ± 0.0 | 1.16 ± 0.0 | 3.02 ± 0.0 | 1.31 ± 0.0 |
| N = 2042 | N = 253 | N = 253 | N = 2042 | |
| NPC1 Males | 148.0 ± 10.0 | 34.9 ± 3.1 | 90.2 ± 7.3 | 120.5 ± 15.7 |
| Age 28.9 ± 3.0 Years | 3.83 ± 0.3 | 0.90 ± 0.1 | 2.33 ± 0.2 | 1.36 ± 0.2 |
| N = 11 | N = 11 | N = 11 | N = 11 | |
| Significance | P = 0.01 | P = 0.01 | P = 0.005 | NS |
| Normal Females | 175.8 ± 0.6 | 56.0 ± 0.8 | 110.2 ± 1.6 | 88.7 ± 1.0 |
| Age 25–29 Years | 4.55 ± 0.0 | 1.45 ± 0.0 | 2.85 ± 0.0 | 1.0 ± 0.0 |
| N = 2189 | N = 314 | N = 314 | N = 2189 | |
| NPC1 Females | 153.0 ± 10.4 | 37.0 ± 2.9 | 87.9 ± 2.6 | 139.7 ± 17.6 |
| Age 26.4 ± 2.6 Years | 3.96 ± 0.3 | 0.96 ± 0.1 | 2.27 ± 0.1 | 1.58 ± 0.2 |
| N = 10 | N = 10 | N = 10 | N = 10 | |
| Significance | NS | P = 0.0001 | P = 0.0001 | P = 0.02 |
The average lipid levels (mean ± S.E.) for normal individuals were obtained from a control population of males and females between the ages of 5–9 and 25–29 years as published in the Lipid Research Clinics Population Studies Data Book by the National Institutes of Health (38). Values in bold are in mg/dl; equivalent values in mmol/l are shown in italics. One-sample t-tests were performed using the mean values for both the gender and age of normal individuals and NPC1 patients to determine significant differences.