TABLE 2.
Plasma LCAT levels, demographic and lifestyle characteristics, and lipid parameters
| LCAT Quartile |
|||||||
|---|---|---|---|---|---|---|---|
| 1 (n = 700) | 2 (n = 684) | 3 (n = 691) | 4 (n = 710) | Pa | Rb | Pb | |
| Age, y | 66.3 (7.4) | 65.5 (7.7) | 65.0 (7.9) | 64.7 (7.7) | <0.001 | −0.54 | 0.005 |
| Current smoker, % (n) | 16 (110) | 10 (69) | 10 (69) | 6.9 (49) | <0.0001c | – | – |
| Former smoker, % (n) | 46 (321) | 52 (355) | 53 (366) | 55 (389) | – | – | – |
| Never smoked, % (n) | 38 (269) | 38 (260) | 37 (256) | 38 (272) | – | – | – |
| Alcohol use, units/weekd | 2.5 (1.0–8.0) | 3.0 (1.0–9.5) | 4.0 (1.0–11) | 4.0 (1.0–12) | <0.0001 | 0.046 | 0.015e |
| BMI, kg/m2 | 25.8 (3.7) | 26.5 (3.4) | 26.8 (3.6) | 27.3 (3.6) | <0.0001 | 0.164 | <0.0001 |
| Waist circumference, cm | 90.0 (12.2) | 92.1 (11.3) | 92.7 (11.0) | 93.9 (11.2) | <0.0001 | 0.086 | <0.0001 |
| Waist hip ratio | 0.88 (0.09) | 0.89 (0.08) | 0.89 (0.08) | 0.90 (0.08) | <0.0001 | 0.018 | 0.345 |
| Diabetes, % (n) | 3.1 (22) | 3.7 (25) | 3.5 (24) | 3.5 (25) | 0.96 | – | – |
| Systolic BP, mmHg | 138 (18.5) | 140 (18.9) | 141 (17.4) | 143 (18.1) | <0.0001 | 0.123 | <0.0001 |
| Diastolic BP, mmHg | 82 (11.6) | 84 (11.8) | 85 (11.2) | 86 (11.2) | <0.0001 | 0.138 | <0.0001 |
| Total cholesterol, mmol/l | 5.9 (1.0) | 6.2 (1.0) | 6.4 (1.1) | 6.8 (1.2) | <0.0001 | 0.315 | <0.0001 |
| LDL-C, mmol/l | 3.8 (0.9) | 4.1 (0.9) | 4.2 (1.0) | 4.5 (1.1) | <0.0001 | 0.241 | <0.0001 |
| HDL-C, mmol/ | 1.3 (0.4) | 1.3 (0.4) | 1.3 (0.4) | 1.3 (0.4) | 0.56 | 0.055 | 0.004 |
| Triglycerides, mmol/ld | 1.4 (1.0–1.9) | 1.6 (1.2–2.2) | 1.7 (1.3–2.4) | 2.0 (1.5–2.7) | <0.0001 | 0.356 | <0.0001e |
| apoA-I, mg/dl | 155.8 (33.2) | 159.4 (27.0) | 161.3 (28.7) | 162.7 (27.2) | <0.001 | 0.103 | <0.0001 |
| apoB, mg/dl | 120.4 (29.3) | 128.9 (29.9) | 132.7 (30.5) | 141.1 (30.6) | <0.0001 | 0.239 | <0.0001 |
Values are mean ± SD or percentage and number of participants.
a
P value for ANOVA of risk factor levels between LCAT quartiles.
b
R indicates Pearson's correlation coefficient between LCAT levels and risk factors and the corresponding P value (b).
c
P value for smoking by χ2 test for trend.
d
Median (interquartile range).
e
Spearman's correlation coefficient between LCAT levels and risk factors and the corresponding P value (P‖).