Analysis of combined effect of alleles associated with low HDL-C. For each participant in the 1990–1995 cohort (A) and the 2000–2003 cohort (B) with complete genotype for 5 LIPC SNPs, alleles associated with low HDL-C were counted (G of rs4775041, C of rs1800588, G of rs11858164, G of rs11856322, and T of rs2242061). Subjects with ≤2 or ≥7 alleles were grouped. N numbers are indicated inside the columns.