TABLE 2.
LIPC SNPs and adjusted plasma HDL-C levels in the 1990–1995 cohort
| AA | AB | BB | P | Permuted P | AA | AB | BB | P | Permuted P | |
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Males | Females | ||||||||
| rs4775041 | 35.2 ± 6.4 (827) | 36.3 ± 6.6 (591) | 36.9 ± 7.3 (106) | 0.0071 | 0.028 | 41.0 ± 8.4 (557) | 40.8 ± 8.0 (396) | 44.4 ± 8.2 (76) | 0.0022 | 0.012 |
| rs16940212 | 35.4 ± 7.2 (991) | 36.0 ± 8.0 (504) | 34.9 ± 7.7 (49) | NS | NS | 41.6 ± 11.0 (708) | 40.5 ± 9.9 (328) | 42.1 ± 10.1 (25) | NS | NS |
| rs1800588 | 35.3 ± 6.5 (962) | 36.5 ± 6.5 (493) | 36.8 ± 6.7 (66) | 0.0110 | 0.048 | 40.5 ± 8.2 (655) | 41.8 ± 8.2 (329) | 45.7 ± 8.1 (46) | 0.0009 | 0.008 |
| rs11858164 | 34.6 ± 5.7 (412) | 36.0 ± 6.2 (772) | 36.5 ± 6.4 (353) | 0.0041 | 0.019 | 40.9 ± 8.0 (297) | 41.7 ± 8.1 (506) | 43.8 ± 7.9 (252) | 0.0025 | 0.017 |
| rs7182229 | 35.7 ± 7.4 (1049) | 35.7 ± 6.9 (435) | 35.4 ± 7.1 (44) | NS | NS | 41.1 ± 9.2 (721) | 41.5 ± 9.2 (286) | 41.5 ± 8.6 (37) | NS | NS |
| rs11856322 | 36.4 ± 6.5 (916) | 35.7 ± 6.5 (535) | 34.3 ± 6.3 (78) | 0.0021 | 0.011 | 42.5 ± 7.5 (627) | 41.4 ± 7.9 (364) | 40.6 ± 6.2 (53) | 0.0028 | 0.013 |
| rs6076 | 36.1 ± 7.4 (1047) | 35.4 ± 7.0 (436) | 35.7 ± 7.2 (49) | NS | NS | 40.9 ± 9.1 (718) | 41.5 ± 9.0 (282) | 41.3 ± 9.5 (44) | NS | NS |
| rs2242061 | 36.0 ± 6.6 (831) | 35.6 ± 6.1 (588) | 34.1 ± 6.1 (106) | 0.0033 | 0.017 | 42.7 ± 8.4 (550) | 41.3 ± 8.4 (402) | 40.7 ± 8.3 (87) | 0.0037 | 0.020 |
| rs690 | 35.7 ± 7.1 (549) | 35.9 ± 7.2 (758) | 35.3 ± 6.9 (219) | NS | NS | 40.5 ± 9.0 (356) | 41.6 ± 8.8 (500) | 41.1 ± 9.1 (188) | NS | NS |
| rs6083 | 36.1 ± 7.2 (680) | 35.6 ± 7.0 (678) | 35.7 ± 7.4 (171) | NS | NS | 41.3 ± 9.1 (490) | 41.2 ± 9.6 (438) | 41.5 ± 10.1 (121) | NS | NS |
| rs11632627 | 36.2 ± 7.3 (845) | 35.5 ± 7.7 (563) | 36.2 ± 7.8 (104) | NS | NS | 41.4 ± 8.9 (564) | 40.9 ± 9.5 (403) | 41.2 ± 8.4 (61) | NS | NS |
All means ± SD were calculated by ANCOVA using general linear models, and adjusted for log triglyceride, age, BMI, smoking, and alcohol consumption. Total number of subjects: 1549 males, 1063 females. Number of subjects for each group is shown in parentheses. P-values were calculated using an additive genetic model in PLINK. Permutation P-values were calculated from 50,000 random iterations in PLINK. NS, not significant. A, common allele; B, rare allele. Significant SNPs are in bold.