TABLE 3.
LIPC SNPs and adjusted plasma HDL-C levels in the 2000–2003 cohort
| AA | AB | BB | P | Permuted P | AA | AB | BB | P | Permuted P | |
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Males | Females | ||||||||
| rs4775041 | 36.0 ± 7.4 (260) | 37.1 ± 9.0 (174) | 39.0 ± 6.7 (33) | 0.0041 | 0.018 | 45.1 ± 9.1 (377) | 46.8 ± 8.2 (264) | 48.3 ± 8.9 (40) | 0.0056 | 0.028 |
| rs16940212 | 37.5 ± 8.8 (325) | 38.2 ± 10.2 (131) | 37.8 ± 9.0 (13) | NS | NS | 46.4 ± 10.3 (478) | 47.1 ± 9.2 (189) | 46.8 ± 9.1 (19) | NS | NS |
| rs1800588 | 36.3 ± 7.8 (298) | 38.6 ± 9.1 (152) | 40.6 ± 8.5 (21) | 0.0011 | 0.008 | 44.9 ± 9.2 (435) | 47.1 ± 8.7 (222) | 49.1 ± 7.9 (28) | 0.0016 | 0.010 |
| rs11858164 | 35.9 ± 8.0 (131) | 38.0 ± 9.4 (234) | 39.1 ± 7.1 (105) | 0.0035 | 0.018 | 44.8 ± 9.1 (196) | 47.0 ± 8.6 (341) | 48.1 ± 9.4 (148) | 0.0031 | 0.013 |
| rs7182229 | 38.5 ± 9.4 (333) | 38.2 ± 10.5 (121) | 39.0 ± 8.8 (20) | NS | NS | 47.0 ± 11.6 (478) | 48.2 ± 11.2 (180) | 45.9 ± 11.4 (28) | NS | NS |
| rs11856322 | 37.2 ± 8.6 (295) | 36.7 ± 8.5 (146) | 33.3 ± 9.0 (32) | 0.0024 | 0.012 | 46.2 ± 8.1 (411) | 44.6 ± 8.0 (236) | 43.3 ± 7.7 (28) | 0.0074 | 0.031 |
| rs6076 | 39.1 ± 9.6 (319) | 38.0 ± 9.6 (136) | 40.2 ± 12.7 (15) | NS | NS | 48.0 ± 12.6 (461) | 46.5 ± 11.0 (202) | 46.9 ± 11.3 (22) | NS | NS |
| rs2242061 | 37.4 ± 7.8 (260) | 37.1 ± 8.8 (174) | 33.3 ± 9.1 (40) | 0.0017 | 0.011 | 46.5 ± 9.1 (372) | 45.7 ± 9.5 (250) | 42.2 ± 9.3 (58) | 0.0022 | 0.012 |
| rs690 | 38.1 ± 10.0 (175) | 37.9 ± 9.2 (215) | 39.0 ± 11.1 (80) | NS | NS | 46.4 ± 11.7 (230) | 47.5 ± 12.0 (315) | 45.5 ± 11.3 (123) | NS | NS |
| rs6083 | 38.4 ± 9.8 (195) | 37.9 ± 10.0 (212) | 38.9 ± 8.1 (65) | NS | NS | 47.3 ± 12.0 (276) | 47.2 ± 12.1 (327) | 48.2 ± 11.8 (85) | NS | NS |
| rs11632627 | 38.4 ± 10.1 (261) | 37.2 ± 10.2 (178) | 39.3 ± 10.2 (35) | NS | NS | 47.5 ± 11.5 (375) | 46.8 ± 12.1 (254) | 48.4 ± 13.2 (46) | NS | NS |
All means ± SD were calculated by ANCOVA using general linear models, and adjusted for log triglyceride, age, BMI, smoking, and alcohol consumption. Total number of subjects: 474 males, 690 females. Number of subjects for each group is shown in parentheses. P-values were calculated using an additive genetic model in PLINK. Permutation P-values were calculated from 50,000 random iterations in PLINK. NS, not significant. A, common allele; B, rare allele. Significant SNPs are in bold.