Table 2.

Adjusted beta coefficients for effect of SBP (per 20 mm Hg) on white matter hyperintensity (WMH) volume change (in cc) between cerebral MRI visits (from visit 3 to visit 5) in the ARIC study.

Systolic blood pressure measurement	Median years from baseline MRI	Beta coefficient* (95% CI): All participants	Beta coefficient** (95% CI): Whites only	Beta coefficient** (95% CI): Blacks only
Visit 1	−5.8 years	1.44 (0.80–2.09)	1.07 (0.19–1.97)	1.98 (1.04–2.92)
Visit 2	−3.0 years	1.47 (0.85–2.10)	1.26 (0.38–2.13)	1.89 (0.99–2.79)
Visit 3: Baseline MRI	0 years	1.10 (0.54–1.67)	1.18 (0.39–1.96)	1.14 (0.32–1.96)
Visit 4	+3.0 years	1.31 (0.73–1.88)	1.93 (1.18–2.68)	0.78 (−0.09–1.66)
Visit 5: Follow-up MRI	+10.6 years	1.28 (0.70–1.85)	1.39 (0.61–2.16)	1.36 (0.51–2.22)
Cumulative mean SBP		2.35 (1.58–3.12)	2.56 (1.56–3.56)	2.48 (1.30–3.67)

^*Adjusted for age, sex, education, prevalent CHD at visit 3, diabetes at visit 3, BMI at visit 3, race, and smoking status at visit 3.

^**Same as above but without adjustment for race