Table 1.
Baseline Characteristics of Participants with and without CKD by Treatment Group
| eGFR ≥ 60 mL/min/1.73m2 | eGFR < 60 mL/min/1.73m2 | P-value | |||
|---|---|---|---|---|---|
| Characteristic | Lovastatin (n=3158) | Placebo (n=3142) | Lovastatin (n=145) | Placebo (n=159) | |
| Age (years) | 58 ± 7 | 58 ± 7 | 62 ± 8 | 62 ± 7.0 | <0.001 |
| Sex N (%) | |||||
| Men | 2686 (85) | 2683 (85) | 119 (82) | 120 (75) | |
| Women | 472 (15) | 459 (15) | 26 (18) | 39 (25) | 0.002 |
| Black N (%) | 103 (3) | 99 (3) | 2 (1) | 2 (1) | 0.06 |
| Hypertension N (%) | 663 (21) | 678 (22) | 56 (39) | 51 (32) | <0.001 |
| Diabetes N (%) | 82 (3) | 68 (2) | 2 (1) | 3 (2) | 0.4 |
| Smoker N (%) | 414 (13) | 380 (12) | 15 (10) | 9 (6) | 0.02 |
| Family History of CAD N (%) | 480 (15) | 516 (16) | 17 (12) | 22 (14) | 0.2 |
| BMI (kg/m2) | 27 ± 3 | 27 ± 3 | 27 ± 3 | 26 ± 3 | 0.03 |
| SBP (mmHg) | 138 ±17 | 138 ± 17 | 140 ± 18 | 143 ± 18 | 0.2 |
| DBP (mmHg) | 78 ± 10 | 78 ± 10 | 79 ± 10 | 79 ± 10 | 0.5 |
| TC (mg/dL) | 220 ± 23 | 220 ± 27 | 224 ± 23 | 220 ± 27 | 0.004 |
| LDL-C (mg/dL) | 147 ± 23 | 147 ± 23 | 151 ± 19 | 151 ± 23 | 0.03 |
| HDL-C (mg/dL) | 39 ± 8 | 39 ± 8 | 39 ± 8 | 39 ± 8 | 0.1 |
| Triglycerides (mg/dL) | 168 ± 80 | 168 ± 71 | 177 ± 71 | 168 ± 80 | 0.2 |
| Medications N (%) | |||||
| Aspirin | 548 (17) | 530 (17) | 22 (15) | 31 (19) | 0.9 |
| Beta Blocker | 130 (4) | 140 (4) | 11 (8) | 16 (10) | <0.001 |
| Calcium channel blocker | 154 (5) | 154 (5) | 17 (12) | 16 (10) | <0.001 |
| Alpha blocker | 66 (2) | 62 (2) | 2 (1) | 5 (3) | 0.7 |
| Diuretic | 182 (6) | 180 (6) | 21 (14) | 23 (14) | <0.001 |
| ACE Inhibitor | 227 (7) | 236 (8) | 17 (12) | 21 (13) | 0.001 |
| SCr (mg/dL) | 0.9 ± 0.2 | 0.9 ± 0.2 | 1.4 ± 0.3 | 1.4 ± 0.2 | <0.001 |
| eGFR (mL/min/1.73m2) | 89 ± 18 | 89 ± 18 | 53 ± 6 | 53 ± 6 | <0.001 |
Values are expressed as mean ± SD or Number (%). P values are comparing the two GFR groups.
Abbreviations: ACE Inhibitor= angiotensin converting enzyme inhibitor; CAD= coronary artery disease; eGFR= estimaged glomerular filtration rate; HDL= high density lipoprotein cholesterol; LDL= low density lipoprotein cholesterol.
Conversion factors for units: total cholesterol in mg/dL to mmol/L, x0.02586; LDL cholesterol in mg/dL to mmol/L, x0.02586; HDL cho mmol/L, x0.02586; triglycerides in mg/dL to mmol/L, x0.01129; creatinine in mg/dL to μmol/L, 88.4.