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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Gene Ther. 2009 Sep 10;17(1):95–104. doi: 10.1038/gt.2009.117

Figure 4. Biomechanical and microCT/functional stimulations demonstrate that Ad-PDGFB and PDGF-BB improve osseointegration in vivo.

Figure 4

Osseointegration index (a), Interfacial stiffness (b), maximum removing load (c), showed significant differences between rhPDGF-BB treatment and the other three groups. Bone volume fractions (d), tissue mineral density (e), and functional tissue modulus (f) demonstrate that 5.5×109 pfu/ml Ad-PDGF-B and rhPDGF-BB displayed significant differences compared to 5.5×108 pfu/ml AD-PDGF-B and Ad-Luc groups. There were no significant differences in tissue mineral density and functional composite tissue apparent modulus at day 14. Data are presented as mean and bars indicate standard error measurement (n=6-8). * p<0.05, Abbreviations: FCAM: functional composite tissue apparent modulus.