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. Author manuscript; available in PMC: 2010 Jan 8.
Published in final edited form as: Pediatrics. 2008 Apr 7;121(5):e1167–e1177. doi: 10.1542/peds.2007-0423

TABLE 4.

Neurodevelopmental Outcomes at 18 to 22 Months’ Corrected Age: Univariate Analyses

Outcomea Group
No IVH/No Shunt
(N = 5163)		 IVH 3/No Shunt
(N = 459)		 IVH 3/Shunt
(N = 103)b 		IVH 4/No Shunt
(N = 311)		 IVH 4/Shunt
(N = 125)c
MDI score
 Mean (SE) 80.6 (0.25) 74.1 (0.91) 66.2 (1.72)d 71.5 (1.09) 60.3 (1.57)d
 Median 82 75 61 72 50
 MDI < 70, n (%) 1318/4807 (27) 183/424 (43) 59/99 (60)e 143/295 (48) 87/115 (76)d
 MDI = 49, n (%) 294/4805 (6) 70/424 (17) 32/99 (32)d 60/295 (20) 55/115 (48)d
PDI score
 Mean (SE) 84.7 (0.25) 77.4 (0.97) 64.1 (1.88)d 73.2 (1.17) 55.2 (1.24)d
 Median 87 82 51 75 49
 PDI < 70, n (%) 810/4741 (17) 140/417 (34) 65/100 (65)d 123/294 (42) 98/114 (86)d
 PDI = 49, n (%) 313/4738 (7) 73/417 (18) 39/100 (39)d 76/294 (26) 74/114 (65)d
CP, n (%) 492/5125 (10) 103/457 (23) 58/102 (57)d 114/310 (37) 100/125 (80)d
Vision impairment, n (%) 465/5115 (9) 77/453 (17) 24/100 (24) 64/307 (21) 41/123 (33)e
Hearing impairment, n (%) 73/5091 (1) 25/446 (6) 2/101 (2) 12/304 (4) 6/119 (5)
NDI, n (%) 1690/4764 (35) 234/426 (55) 79/101 (78)d 189/299 (63) 114/124 (92)d
a

Information was missing for MDI (421), PDI (495), CP (42); vision impairment (63), hearing impairment (100), and NDI (447).

b

Statistically significant comparisons between IVH 3/shunt versus IVH 3/no shunt are shown. Comparisons between IVH 3/shunt versus no IVH/no shunt were statistically significant for all outcomes (P < .001) except hearing impairment (P = .6).

c

Statistically significant comparisons between IVH 4/shunt versus IVH 4/no shunt are shown. Comparisons between IVH 4/shunt versus no IVH/no shunt were statistically significant for all outcomes (P < .001 for all, except hearing impairment P < .01).

d

P ≤ .001,

e

P ≤ .01 for IVH 3/shunt versus IVH 3/no shunt or for IVH 4/shunt versus IVH 4/no shunt by the χ2 or Wilcoxon test.