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. Author manuscript; available in PMC: 2010 Jan 8.
Published in final edited form as: Oral Dis. 2008 Jan;14(1):10–14. doi: 10.1111/j.1601-0825.2007.01419.x

Table 1.

Contraindications to treatment with peginterferon and ribavirin

Absolute contraindications

  1. Pregnancy

  2. Breast feeding

  3. Allergic reaction to either drug

Relative contraindications

  1. Decompensated liver disease as defined by bilirubin >1.5 mg dl−1, prothrombin time >15 s or INR ≥1.7, albumin <3.4 g dl−1, ascites, bleeding esophageal varices, hepatic encephalopathy

  2. Neuropsychiatric diseases

  3. Coronary artery disease

  4. Cerebrovascular disease

  5. Renal failure

  6. Previous organ transplantation

Close monitoring and dose adjustment might be required in patients with anemia, thrombocytopenia or leucopenia. Patients with renal dysfunction might need adjustment of ribavirin dose.