Table 3.
Genetic polymorphisms in combination of ERCC1 and XRCC1 and survival of patients
| Stage | Combined genotype | Patients(%) | MST(mon) | Log-rank P | HR(95%CI)a |
|---|---|---|---|---|---|
| all | 0 variant | 67(26.1) | 25.10 | 1.00 | |
| 1 variant allele | 100(38.9) | 13.07 | 1.52(1.04-2.22) | ||
| 2 variant alleles | 58(22.6) | 9.27 | < 0.001 | 2.33(1.54-3.50) | |
| 3 variant alleles | 26(10.1) | 6.30 | 2.98(1.76-5.04) | ||
| 4 variant alleles | 6(2.3) | 3.87 | 9.24(3.50-24.44) | ||
| I and II | 0 variant | 26(33.3) | 45.80 | 1.00 | |
| 1 variant allele | 30(38.5) | 22.27 | 1.98(0.86-4.58) | ||
| 2 variant alleles | 14(17.9) | 11.60 | 0.145 | 2.81(1.10-7.13) | |
| 3 variant alleles | 6(7.7) | --b | 1.41(0.26-6.75) | ||
| 4 variant alleles | 2 (2.6) | 17.27 | 9.05(1.04-78.76) | ||
| III and IV | 0 variant | 41(22.9) | 19.10 | 1.00 | |
| 1 variant allele | 70(39.1) | 11.17 | 1.54(0.98-2.39) | ||
| 2 variant alleles | 44(24.6) | 8.93 | < 0.001 | 2.29(1.44-3.66) | |
| 3 variant alleles | 20(11.2) | 5.83 | 3.69(2.06-6.62) | ||
| 4 variant alleles | 4(2.2) | 3.63 | 18.50(5.68-60.23) |
Abbreviation: MST, median survival time; HR, hazard ratio; CI, confidence interval.
aHR adjusted for age, stage, surgical operation and chemotherapy or radiotherapy.
bMST for this genotype could not be calculated.