Table 1.
Effect of artemether and mefloquine against juvenile Schistosoma mansoni harbored in NMRI and NMRI nude mice*
| Mouse strain | Drug (dosage [mg/kg]) | No. of mice investigated | No. of mice cured | Mean number of worms (SD) | Total worm burden reduction (%) | KW | P value | Female worm burden reduction (%) | KW | P value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver | Mesenteric veins | Total | Males | Females | ||||||||||
| NMRI | – | 9† | 0 | 1.0 (1.3) | 17.0 (10.6) | 18.0 (10.3) | 9.4 (5.1) | 8.6 (5.5) | – | – | – | – | – | – |
| Artemether (400) | 5 | 1 | 0 | 4.4 (4.3) | 4.4 (4.3) | 2.4 (2.3) | 2.0 (2.0) | 75.6 | 6.78 | 0.009 | 76.8 | 6.85 | 0.009 | |
| Mefloquine (200) | 5 | 4 | 0 | 0.4 (0.9) | 0.4 (0.9) | 0.2 (0.4) | 0.2 (0.4) | 97.8 | 9.20 | 0.002 | 97.7 | 9.24 | 0.002 | |
| NMRI nude | – | 6‡ | 0 | 2.8 (1.9) | 21.7 (6.9) | 24.5 (7.9) | 13.5 (4.6) | 11.0 (3.5) | – | – | – | – | – | – |
| Artemether (400) | 5 | 1 | 1.8 (2.7) | 1.8 (1.5) | 3.6 (3.2) | 1.6 (1.7) | 2.0 (1.6) | 85.3 | 7.50 | 0.006 | 81.8 | 7.56 | 0.006 | |
| Mefloquine (200) | 5 | 1 | 1.6 (1.5) | 1.0 (1.7) | 2.6 (3.1) | 1.2 (1.6) | 1.4 (1.5) | 89.4 | 7.53 | 0.006 | 87.3 | 7.63 | 0.005 | |
*
SD = standard deviation; KW = Kruskal Wallis.
†
One mouse died during the course of infection.
‡
Two mice died during the course of infection.