Table 2.
Effect of artemether and mefloquine against adult Schistosoma mansoni harbored in NMRI and NMRI nude mice*
| Mouse strain | Drug (dosage [mg/kg]) | No. of mice investigated | No. of mice cured | Mean number of worms (SD) | Total worm burden reduction (%) | KW | P value | Female worm burden reduction (%) | KW | P value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liver | Mesenteric veins | Total | Males | Females | ||||||||||
| NMRI | – | 9† | 0 | 1.0 (1.3) | 17.0 (10.6) | 18.0 (10.3) | 9.4 (5.1) | 8.6 (5.5) | – | – | – | – | – | – |
| Artemether (400) | 5 | 0 | 3.6 (2.3) | 1.6 (1.7) | 5.2 (3.3) | 3.6 (1.9) | 1.6 (1.5) | 71.1 | 6.76 | 0.009 | 81.4 | 7.52 | 0.006 | |
| Mefloquine (200) | 4† | 1 | 2.3 (1.7) | 0 | 2.3 (1.7) | 2.0 (1.8) | 0.3 (0.5) | 87.2 | 7.74 | 0.006 | 96.5 | 7.84 | 0.005 | |
| NMRI nude | – | 6‡ | 0 | 2.8 (1.9) | 21.7 (6.9) | 24.5 (7.9) | 13.5 (4.6) | 11.0 (3.5) | – | – | – | – | – | – |
| Artemether (400) | 4† | 0 | 5.5 (3.1) | 0.5 (1.0) | 6.0 (3.4) | 3.0 (1.4) | 3.0 (2.0) | 75.5 | 6.59 | 0.01 | 72.7 | 6.70 | 0.009 | |
| Mefloquine (200) | 4§ | 1 | 4.8 (3.2) | 0 | 4.8 (3.2) | 2.3 (1.5) | 2.5 (1.7) | 80.4 | 6.59 | 0.01 | 77.3 | 6.70 | 0.009 | |
*
SD = standard deviation; KW = Kruskal Wallis.
†
One mouse died during the course of infection.
‡
Two mice died during the course of infection.
§
Three mice died during the course of infection.