Patient category	Advantage
Children (e23)	Children have low levels of creatinine and determination is unreliable in the low er range of measurement
The elderly (e15)	Owing to physiological reduction in renal function and decrease in muscle mass, cystatin C correlates better than creatinine with inulin clearance
Myasthenics, leg amputees, paraplegics (e16)	Because of the lower muscle mass, creatinine synthesis is low and creatinine-based eGFR is late to detect renal failure
Diabetics (e17)	Early stages of renal failure are detected more reliably with cystatin C based than with creatinine-based eGFR
Liver cirrhosis (18)	Creatinine methods are slow to detect the decrease in GFR because creatinine metabolism in the liver is reduced
Cytostatic treatment (e19)	The nephrotoxicity of cisplatin is dose-dependent and a reduction in GFR is detected earlier by cystatin C-based than by creatinine-based eGFR