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. 2009 Mar 17;17(5):778–786. doi: 10.1038/mt.2009.47

Figure 7.

Figure 7

Increased expression of superoxide dismutase 2 (SOD2) and Catalase preserves some cone cell function at postnatal day (P) 50 in rd10+/+ mice. (a) Scotopic electroretinograms (ERGs) were done at P35 in null-rd10+/+, Sod2-rd10+/+, Catalase-rd10+/+, and Sod2/Catalase-rd10+/+ mice treated with doxycycline. The mean (±SEM) b-wave amplitude for four different stimulus intensities is plotted for each of four groups of mice and there were no significant differences. (b) Low background photopic ERGs were done as described in Materials and Methods at P50. Representative waveforms are shown for each of the four groups and illustrate a substantially better waveform in Sod2/Catalase-rd10+/+ mice compared to null-rd10+/+, Sod2-rd10+/+, or Catalase-rd10+/+ mice. The bars show mean (±SEM) photopic b-wave amplitude, which was significantly higher (**P < 0.01 by Tukey–Kramer test) for Sod2/Catalase-rd10+/+ mice compared to the other three types of mice.