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. Author manuscript; available in PMC: 2010 Jan 8.
Published in final edited form as: Acta Physiol (Oxf). 2009 Sep 1;198(1):1–13. doi: 10.1111/j.1748-1716.2009.02037.x

Figure 2.

Figure 2

Possible mechanism for fibrinogen (Fg)-induced vasoconstriction. Fg binds to endothelial intercellular adhesion molecule-1 (ICAM-1) and possibly α5β1 integrin, induces activation of extracellular signal-regulated kinase-1/2 (ERK-1/2) signalling causing exocytosis of Weibel-Palade bodies (WPbs), formation of endothelin-1 (ET-1), and thus subsequent vasoconstriction through involvement of endothelin type A and B receptors (ET-A and ET-B respectively). Notice a negative feedback loop that involves ET-B-induced activation of ERK-1/2 signalling. Printed with permission from Sen et al. (2009).