. 2009 Oct 20;115(1):21–28. doi: 10.1182/blood-2009-06-195370

Table 2.

Differential diagnosis for HCL

Disease	Immunophenotype	Other features
HCL	CD11c, CD25, CD103, CD123, annexin A1⁺, CD20^bright	Monocytopenia, frequent leukopenia
Hairy cell variant	CD11c, CD103, CD25⁻	No monocytopenia, high leukemic cell count
SMZL/SLVL	CD11c, CD25, CD24, CD79b
Chronic lymphocytic leukemia	CD5, CD19, CD23
B-prolymphocytic leukemia	CD19, FMC7, CD79b, CD20, and CD22^bright	High leukocyte count

SMZL/SLVL indicates splenic marginal zone lymphoma/splenic lymphoma with villous lymphocytes. This entity may occasionally be CD103⁺. In addition, CD11c has also been reported to be positive in a subset of these patients.